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KMID : 0869619990160010052
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Journal of Korean Society of Hospital Pharmacists
1999 Volume.16 No. 1 p.52 ~ p.55
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The Content Uniformity and Dissolution Rate of Acetaminophen Tablets
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Abstract
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Acetaminophen is the drug that the analgesic and antipyretic action by raising the threshold of pain dilation of peripheral vein. Acetaminophen tablets are sold in about sixty manufactures. But, although these drugs are equal manufactureally, the efficacy, and bioavailability may not be equal. So this study was attempted to evaluate the efficacy, the bioavailability of four different brands by content uniformity test and dissolution test.
The result were following
1) Content uniformity of four different brands was in the range of 90∼110%, that is a standard uniformity of K.P. Ⅶ.
2) The dissolution rate in artificial gastric juice (pH 1.2) after 30 minutes was higher in the order of four different brands A>B>C>D.
3) The dissolution rate in artificial intestinal juice (pH 6.5) after 30 minutes was higher in the order of four different brands D>B>A>C.
4) There was no relationship between content uniformity and dissolution rate.
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